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conferences:usgeb11 [2013/07/04 08:45] (current)
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 +====== Notes from USGEB11 ======
 +[[http://​www.usgeb2011.uzh.ch/​|USGEB Meeting 2011, Zurich «Imaging Life»]]
 +====== Thursday 27.01.2011 ======
 +===== Plenary Lecture I =====
 +Seeing Cells in Action with photoactivatable fluorescent Proteins ​ - Jennifer Lippincott-Schwartz
 +  * Photo-activated light microscopy -> Super-resolution
 +  * Autophagy -> self-destruction of cell
 +  * correlative imaging [[https://​secure.wikimedia.org/​wikipedia/​en/​wiki/​Microscopy#​PALM.2C_STORM|PALM]]/​TEM -> map molecules on Electron microscopy images
 +  * 3D imaging possible
 +    * wave from photon is propagated through two objectives
 +    * interference makes it possible to extract 3D position
 +===== Brain Imaging - Symposium D =====
 +==== Rolf Grütter - Imaging Brain Metabolism ====
 +  * Brain glucose level is linear to plasma glucose
 +  * Brain glucose content mapped using <​sup>​1</​sup>​H [[wp>​NMR]]
 +  * Spectroscopy can be used to emasuera concentration of biochemical compounds
 +    * Concentration > 1 MM
 +    * water soluble
 +  * -> quantitative tool
 +==== Corrado Corradi - felt and observed pain... ====
 +  * Analysis of activation patterns of brain regions of observed and experienced pain -> localized in one single part of the brain
 +==== Beat Riederer - Imaging Brain Protein ====
 +==== Christophe Lamy - Imaging Sodium in Tissue ====
 +===== Exploring Biological Matter by Different Imaging Modalities - Symposium H =====
 +==== C. Cremer Nanoscopy of Nuclear Architecture ====
 +  * distribution of cells in Nucleus -> Super-resolution
 +  * Merging of several images together
 +==== David  Müller ====
 +  * AFM imaging
  
 +====== Friday 28.01.2011 ======
 +===== Imaging life using PET - Symposium J =====
 +==== Introduction ====
 +  * PET is quantitative,​ but had only a resolutin in the mm-range
 +<​markdown>​
 +==== Windhorst - New PET Pharaceuticals in Oncology ====
 +  * Translational molecular imaging
 +  * Molecular labeling with different compounds
 +  * Makes personalized treatment possible, but needs testing for treatment with specific FDG-marker
 +==== Tony Gee - PET in the CNS ====
 +  * Since markers have short half life, repeated studies are possible
 +  * <​sup>​11</​sup>​C has 20min half life
 +  * Enzymes can be used, even Cocaine, Heroin and Nicotine. Can even be done without the pharmacological effect, since the markers can be labeled (which destroys the effect?)
 +  * For antidepressants,​ a combination of Pindolol and SSRI was shown to improve onset of action. 70% of 5-HT1A - Receptor has to be occupied by Pindolol.
 +
 +==== Surekha Pimple - Evaluation of Quinazoline as PET Tracers ====
 +  * Development and characterization of new tracers for PET imaging
 +
 +==== Haibiao Gong - in vigo imaging of xenograft tumors ====
 +  * Near infrared imaging of tumors in vivo, follows by ex vivo imaging of the whole organ and tissue sectioning
 +  * Activation of [[http://​en.wikipedia.org/​wiki/​Affibody_molecule|Affibodies]] could be detected.
 +
 +==== Jana Doehner - Role of Reelin in brain tissue ====
 +  * Plays a role in Alzheimer research
 +  * Expression of Reelin changes over aging
 +  * Similarities between human and mouse plaques
 +
 +===== Plenary Lecture =====
 +==== Fritjof Helmchen - Emerging techniques for in vivo imaging of Neural Circuit Dynamics ====
 +  * Neocortex has several layers of neurons until the white matter
 +  * Depth penetration into Neocortex around 800 um, into living tissue!
 +  * Single action potentials through imaging combined wit electrical recording
 +  * Two-photon imaging with '​swinging objective'​ to cover full ROI
 +  * Tradeoff between time resolution and size of Neuron population which can be imaged
 +  * Plasticity effect in the brain (due to trimming of whiskers)
 +  * Imaging in awake and behaving mice an be done with animals which are trained to tolerate head fixation