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+ | ====== Notes from USGEB11 ====== | ||
+ | [[http:// | ||
+ | ====== Thursday 27.01.2011 ====== | ||
+ | ===== Plenary Lecture I ===== | ||
+ | Seeing Cells in Action with photoactivatable fluorescent Proteins | ||
+ | * Photo-activated light microscopy -> Super-resolution | ||
+ | * Autophagy -> self-destruction of cell | ||
+ | * correlative imaging [[https:// | ||
+ | * 3D imaging possible | ||
+ | * wave from photon is propagated through two objectives | ||
+ | * interference makes it possible to extract 3D position | ||
+ | ===== Brain Imaging - Symposium D ===== | ||
+ | ==== Rolf Grütter - Imaging Brain Metabolism ==== | ||
+ | * Brain glucose level is linear to plasma glucose | ||
+ | * Brain glucose content mapped using < | ||
+ | * Spectroscopy can be used to emasuera concentration of biochemical compounds | ||
+ | * Concentration > 1 MM | ||
+ | * water soluble | ||
+ | * -> quantitative tool | ||
+ | ==== Corrado Corradi - felt and observed pain... ==== | ||
+ | * Analysis of activation patterns of brain regions of observed and experienced pain -> localized in one single part of the brain | ||
+ | ==== Beat Riederer - Imaging Brain Protein ==== | ||
+ | ==== Christophe Lamy - Imaging Sodium in Tissue ==== | ||
+ | ===== Exploring Biological Matter by Different Imaging Modalities - Symposium H ===== | ||
+ | ==== C. Cremer Nanoscopy of Nuclear Architecture ==== | ||
+ | * distribution of cells in Nucleus -> Super-resolution | ||
+ | * Merging of several images together | ||
+ | ==== David Müller ==== | ||
+ | * AFM imaging | ||
+ | ====== Friday 28.01.2011 ====== | ||
+ | ===== Imaging life using PET - Symposium J ===== | ||
+ | ==== Introduction ==== | ||
+ | * PET is quantitative, | ||
+ | < | ||
+ | ==== Windhorst - New PET Pharaceuticals in Oncology ==== | ||
+ | * Translational molecular imaging | ||
+ | * Molecular labeling with different compounds | ||
+ | * Makes personalized treatment possible, but needs testing for treatment with specific FDG-marker | ||
+ | ==== Tony Gee - PET in the CNS ==== | ||
+ | * Since markers have short half life, repeated studies are possible | ||
+ | * < | ||
+ | * Enzymes can be used, even Cocaine, Heroin and Nicotine. Can even be done without the pharmacological effect, since the markers can be labeled (which destroys the effect?) | ||
+ | * For antidepressants, | ||
+ | |||
+ | ==== Surekha Pimple - Evaluation of Quinazoline as PET Tracers ==== | ||
+ | * Development and characterization of new tracers for PET imaging | ||
+ | |||
+ | ==== Haibiao Gong - in vigo imaging of xenograft tumors ==== | ||
+ | * Near infrared imaging of tumors in vivo, follows by ex vivo imaging of the whole organ and tissue sectioning | ||
+ | * Activation of [[http:// | ||
+ | |||
+ | ==== Jana Doehner - Role of Reelin in brain tissue ==== | ||
+ | * Plays a role in Alzheimer research | ||
+ | * Expression of Reelin changes over aging | ||
+ | * Similarities between human and mouse plaques | ||
+ | |||
+ | ===== Plenary Lecture ===== | ||
+ | ==== Fritjof Helmchen - Emerging techniques for in vivo imaging of Neural Circuit Dynamics ==== | ||
+ | * Neocortex has several layers of neurons until the white matter | ||
+ | * Depth penetration into Neocortex around 800 um, into living tissue! | ||
+ | * Single action potentials through imaging combined wit electrical recording | ||
+ | * Two-photon imaging with ' | ||
+ | * Tradeoff between time resolution and size of Neuron population which can be imaged | ||
+ | * Plasticity effect in the brain (due to trimming of whiskers) | ||
+ | * Imaging in awake and behaving mice an be done with animals which are trained to tolerate head fixation |