Spectroscopy can be used to emasuera concentration of biochemical compounds
Concentration > 1 MM
water soluble
→ quantitative tool
Corrado Corradi - felt and observed pain...
Analysis of activation patterns of brain regions of observed and experienced pain → localized in one single part of the brain
Beat Riederer - Imaging Brain Protein
Christophe Lamy - Imaging Sodium in Tissue
Exploring Biological Matter by Different Imaging Modalities - Symposium H
C. Cremer Nanoscopy of Nuclear Architecture
distribution of cells in Nucleus → Super-resolution
Merging of several images together
David Müller
AFM imaging
Friday 28.01.2011
Imaging life using PET - Symposium J
Introduction
PET is quantitative, but had only a resolutin in the mm-range
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Windhorst - New PET Pharaceuticals in Oncology
Translational molecular imaging
Molecular labeling with different compounds
Makes personalized treatment possible, but needs testing for treatment with specific FDG-marker
Tony Gee - PET in the CNS
Since markers have short half life, repeated studies are possible
11C has 20min half life
Enzymes can be used, even Cocaine, Heroin and Nicotine. Can even be done without the pharmacological effect, since the markers can be labeled (which destroys the effect?)
For antidepressants, a combination of Pindolol and SSRI was shown to improve onset of action. 70% of 5-HT1A - Receptor has to be occupied by Pindolol.
Surekha Pimple - Evaluation of Quinazoline as PET Tracers
Development and characterization of new tracers for PET imaging
Haibiao Gong - in vigo imaging of xenograft tumors
Near infrared imaging of tumors in vivo, follows by ex vivo imaging of the whole organ and tissue sectioning